Cajal’s challenge accepted: Sharpening the tool box for in vivo cell fate conversion

Direct lineage reprogramming in vivo emerges as a novel approach for the repair of tissues with little intrinsic regenerative capacity. Recent years have seen a tremendous amount of progress, providing proof-of-principle evidence for the feasibility of converting cell fate in the brain, pancreas, and the heart. In the brain, glia-to-neuron conversion opens potential avenues to regenerate neurons lost due to injury or neurodegenerative disease. However, to move the field from proof-of-principle to preclinical studies requires an improved toolbox that allows precise targeting of starting cells, their efficient cell fate conversion, and unambiguous proof thereof. In this one-day satellite workshop, we aim at bringing together leaders in the field to discuss the current state-of-the-art as well as barriers impeding progress. A special focus is placed on sharpening our molecular toolbox available for direct in vivo lineage reprogramming and the best strategies to prove its authenticity.


Speaker list

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Ana Martin-Villalba

Onset of differentiation is post-transcriptionally controlled in adult neural stem cell

German Cancer Research Center, Germany

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Benedikt Berninger

Engineering new interneurons in the postnatal cerebral cortex

Kings College London, UK

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Christophe Heinrich

Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy

Stem Cell Brain Research Institute, France

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Chun-Li Zhang

Induced adult neurogenesis from NG2 glia for spinal cord injury

University of Texas Southwestern, US

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Don Cleveland

Identity theft: Generation of new neurons in a therapeutic viable approach

University of California at San Diego, US

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Kinichi Nakashima

Regeneration of CNS functions by inducing artificial neurogenesis through regulating epigenetics, stem cells and cell fate conversion

Kyushu University, Japan

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Malin Parmar

Direct conversion of human glia to neurons in vitro and after transpantation in a rat model

Lund University, Sweden

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Paola Arlotta

Can neurons change glia in the cerebral cortex?

Harvard Stem Cell Institute, US

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Seth Blackshaw

Repressing neurogenic competence in brain and retinal glia

Johns Hopkins University, US

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Thomas Reh

Comparative biology of vertebrate retinal regeneration: restoration of vision through cellular reprogramming

University of Washington, US



08:45 am - 09:00 am

Morning coffee and gathering

09:00 am - 12:45 pm

Morning session

12:45 pm - 01:45 pm

Lunch break

01:45 pm - 04:45 pm

Afternoon session

04:45 pm - 05:30 pm

Discussion and closing remarks

05:30 pm - 07:00 pm

Posters and Networking



We are in the process of applying for funds

If you are interest to contribute to this event please contact us



Registration is free!

Please use the short form (or email us your details) in the right to register. The event is in person only.

Important: we have limited capacity for researchers who are willing to join us and/or present a poster. First come first serve. We have only ~40 spaces available.

Abstract submission deadline - June 15th, 2022.  

For general inquiries about the workshop: "Cajal’s challenge accepted: Sharpening the tool box for in vivo cell fate conversion" or more information about speakers, sponsorship, or other general questions please get in touch with us via our email address below.

+1 (858) 2959921 ; +1 (858) 3448128

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